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The effect of a weight loss on bone and energy metabolism in premenopausal women with obesity
Malinová, Pavlína ; Zikán, Vít (advisor) ; Michalská, Dana (referee)
Introduction: Current findings show that obesity may not only have a protective effect in terms of the osteoporosis development. Although higher mechanical load on bones in obese people increases bone mass density, inflammatory cytokines produced by adipose tissue, on the contrary, increase bone resorption. The reduction of body weight itself can contribute to the deterioration of the quality of bone mass. Aim: The main aim of the study was to evaluate changes in BMD and selected parameters of body composition during a 2-month strict very low-calorie diet (VLCD) and a subsequent 4-month low-calorie diet (LCD) in premenopausal women with obesity. Methods: The study was carried out at the workplaces of the III. Internal Clinic of the General University Hospital in Prague and the Institute of Endocrinology in Prague. Data were collected in the period from April 2021 to May 2023. 11 patients participated in the study with dietary intervention, data was processed from 10 of them. The average age was 44.1 ± 9.3 years, the average weight was 94 ± 10.4 kg. The control group consisted of 14 patients, 10 of them were included in the study. The average age in the control group was 40.7 ± 6.4 years, the average weight was 64.4 ± 7.5 kg. Patients of the intervention group were given a very low-calorie diet with...
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Long-term effects of short-term low calorie and very low calorie diets
Čmerdová, Kristýna ; Matoulek, Martin (advisor) ; Mikeš, Ondřej (referee)
Starting points: LCD and VLCD are one of the possibilities, which can be used when battling obesity. They are not however advised separately. There must always be present another form of treatment. What follows is either bariatric treatment, or a home reduction plan in cooperation with a nutrition therapist. LCD or VLCD should always be under the supervision of a doctor. Goals: To, in detail, describe a complex of patients, who were on weight reduction hospital stay (later only WRHS), as a foundation of a statistical analysis of dynamic changes concerning the reasoning of LCD and VLCD hospitalization, basic anthropometric data and deduce the short and long-term effect of WRHS with LCD and VLCD. Methods: Entry data were collected retroactively from hospital records of patients who were hospitalized for reduction of weight in the years 2014-2015 in inpatient ward D3 of the third Internal clinic of the General University Hospital in Prague (Všeobecná fakultní nemocnice v Praze). This data was statistically processed and its results discussed and charted in this paper. Main results: The most common reasoning for WRHS was sole reduction of weight; next was bariatric operation after WRHS. Patients who didn't undergo bariatric operation within a year of their 1.st WRHS, and their weight after one year is...
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